Neuroprotection

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Aguado T, Romero E, Monory K, Palazuelos J, Sendtner M, et.al. (2007). The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis. J Biol Chem., 282(33), 23892-8.

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Benito,C., Nunez, E., Tolo, R.M., Carrier, E.J., Rabano, A., et.al. (2003). Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer�s Disease brains. J. Neurosci, 23(35),11136 �11141.

Benito C, Romero JP, Tol�n RM, Clemente D, Docagne F, et.al. (2007). Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. J Neurosci., 27(9), 2396-402.

Benito, C., Tolon, R.M., Pazos, M.R., Nunez, E., Castillo, A.I., et al. (2008). Cannabinoid CB2 receptors in human brain inflammation. Br. J. Pharmacol. 153 (2), 277�285.

Campbell VA & Gowran A. (2007). Alzheimer's disease; taking the edge off with cannabinoids?
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Centonze, D., Finazzi-Agro, A., Bernardi, G., & Maccarrone, M. (2007). The endocannabinoid system in targeting inflammatory neurodegenerative diseases. Trends Pharmacol Sci, 28(4) 180-187.

Chen J, Lee CT, Errico SL, Becker KG, &Freed WJ. (2007). Increases in expression of 14-3-3 eta and 14-3-3 zeta transcripts during neuroprotection induced by delta9-tetrahydrocannabinol in AF5 cells. J Neurosci Res., 85(8), 1724-33.

Chen J, Lee CT, Errico S, Deng X, Cadet JL, & Freed WJ. (2005). Protective effects of Delta(9)-tetrahydrocannabinol against N-methyl-d-aspartate-induced AF5 cell death. Brain Res Mol Brain Res.,134(2), 215-25.

Ehrhart, J., Obregon, D., Mori, T., Hou, H., Sun, N., et.al. (2005). Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. J. Neuroinflam., 2(29), doi:10.1186/1742-2094-2-29.

El-Remessy AB, Khalil IE, Matragoon S, Abou-Mohamed G, Tsai NJ, et.al. (2003). Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite. Am J Pathol., 163(5), 1997-2008.

Eubanks, L.M., Rogers, C.J., Beuscher IV, A.E., Koob, G.F., Olson, A.J., et.al. (2006). A molecular link between the active component of marijuana and Alzheimer�s Disease pathology. Mol. Pharm. 3(6) 773-777.

Karanian DA, Brown QB, Makriyannis A, Kosten TA, & Bahr BA. (2005). Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity. J Neurosci., 25(34), 7813-20.

Kim SH, Won SJ, Mao XO, Ledent C, Jin K, & Greenberg DA. (2006). Role for neuronal nitric-oxide synthase in cannabinoid-induced neurogenesis. J Pharmacol Exp Ther., 319(1), 150-4.

Kim SH, Won SJ, Mao XO, Jin K, & Greenberg DA. (2005). Involvement of protein kinase A in cannabinoid receptor-mediated protection from oxidative neuronal injury. J Pharmacol Exp Ther., 313(1):88-94.

Leker RR, Gai N, Mechoulam R, & Ovadia H. (2003). Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210. Stroke, 34(8), 2000-6.

Mach F, Montecucco F, & Steffens S. (2008). Cannabinoid receptors in acute and chronic complications of atherosclerosis. Br J Pharmacol., 153(2), 290-8.

Malfait, A. M., Gallily, R., Sumariwalla, P. F., Malik, A. S., Andreakos, E., Mechoulam, R., et al. (2000). The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci U S A, 97(17), 9561-9566.

Mechoulam R, & Hanu L. (2001). The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection. Pain Res Manag., 6(2), 67-73.

Palazuelos J, Davoust N, Julien B, Hatterer E, Aguado T, et.al (2008). The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis. J Biol Chem. 283(19), 13320-9.

Pryce G, Ahmed Z, Hankey DJ, Jackson SJ, Croxford JL, et.al. (2003). Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Brain, 126(10), 2191-202.

Ram�rez BG, Bl�zquez C, G�mez del Pulgar T, Guzm�n M, & de Ceballos ML. (2005). Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J Neurosci. 25(8), 1904-13.

Sagredo, O., Garc�a-Arencibia, M., de Lago, E., Finetti, S., Decio, A., et.al (2007). Cannabinoids and Neuroprotection in basal ganglia disorders. Mol Neurobiol, 36(1), 82�91

Shouman B, Fontaine RH, Baud O, Schwendimann L, Keller M, et.al. (2006). Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage. Br J Pharmacol., 148(4), 442-51.

Sun Y, Alexander SP, Garle MJ, Gibson CL, Hewitt K, et.al. (2007). Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism. Br J Pharmacol. 152(5), 734-43.

van der Stelt M, Veldhuis WB, B�r PR, Veldink GA, Vliegenthart JF, et.al. (2001). Neuroprotection by Delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity. J Neurosci.,21(17), 6475-9.

Walther, S., Mahlberg, R., Eichmann,U. & Kunz, D. (2006). Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia. Psychopharmacol 185(4), 524�528.

Witting A, Chen L, Cudaback E, Straiker A, Walter L, et.al. (2006). Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection. Proc Natl Acad Sci U S A., 103(16), 6362-7.

Zani A, Braida D, Capurro V, & Sala M. (2008). Delta9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors. Br J Pharmacol. 152(8), 1301-11.

Zhang M, Martin BR, Adler MW, Razdan RK, Ganea D, et.al. (2008). Modulation of the balance between cannabinoid CB(1) and CB(2) receptor activation during cerebral ischemic/reperfusion injury. Neurosci.,152(3), 753-60.